Respect for your privacy is our priority

The cookie is a small information file stored in your browser each time you visit our web page.

Cookies are useful because they record the history of your activity on our web page. Thus, when you return to the page, it identifies you and configures its content based on your browsing habits, your identity and your preferences.

You may accept cookies or refuse, block or delete cookies, at your convenience. To do this, you can choose from one of the options available on this window or even and if necessary, by configuring your browser.

If you refuse cookies, we can not guarantee the proper functioning of the various features of our web page.

For more information, please read the COOKIES INFORMATION section on our web page.


News

Research: New data on tomatoes and lycopene anti-prostate cancer activity

20/07/2022 - Sophie Colvine
Epidemiology studies have suggested protection against prostate cancer is derived from consuming tomato products or a major carotenoid found in them, lycopene.  The heterogenous nature of prostate cancers, and the difficulty in having precise measures of tomato consumption makes it hard to fully understand the impact of tomato products on prostate cancer, and importantly to establish a causal relation between them.  Therefore, to design effective human intervention studies, it is necessary to define optimal methods for delivery (food vs pure lycopene), the dose, duration, and timing of exposures.  Moran and colleagues have performed a review of the literature for various animal models of prostate cancer in order to explore these variables in controlled experiments and report the results of their review in the June 2022 issue of The Journal of Nutrition.

Data were derived from 21 published reports of the impact of different doses of tomatoes, tomato components, or lycopene on tumorigenesis and carcinogenesis in different rodent models.  The models included transplantable xenografts, or chemically- and genetically-driven prostate cancers.

Both tomatoes and tomato components were able to suppress tumorigenesis in the transplant and carcinogenesis in the chemically- and genetically-driven cancer types.  Lycopene was effective in most model systems, but the response was dependent on dose, duration, and type of carcinogenic process.  Efficacy was typically higher when the interventions were started earlier and lasted longer.  The data suggest that lycopene may not be the only compound in tomatoes with anti-prostate cancer activity.  The authors conclude that tomatoes and lycopene have anti-cancer activity in rodent models, yet acknowledge that more work is needed to explain dose-response relationships and identify molecular mechanisms of action.  They suggest future studies could provide the information needed to design and execute effective human clinical trials.

Reference:
Nancy E Moran, Jennifer M Thomas-Ahner, Lei Wan, Krystle E Zuniga, John W Erdman, Jr, Steven K Clinton, Tomatoes, Lycopene, and Prostate Cancer: What Have We Learned from Experimental Models?, The Journal of Nutrition, Volume 152, Issue 6, June 2022, Pages 1381–1403.

Full article in free access at:

https://doi.org/10.1093/jn/nxac066

Source: American Society for Nutrition
Related articles

Research: Tomato products and prostate cancer

23/08/2021 See details

Paint Your Plate Red to Fight Prostate Cancer

13/11/2018 See details
Back

________________________________________

Editor : TOMATO NEWS SAS -  MAISON DE L'AGRICULTURE - TSA 48449 - 84912 AVIGNON Cedex 9 - FRANCE
contact@tomatonews.com
www.tomatonews.com

 

 

Supporting partners
Featured company
Lark Seeds International
Most popular news
Featured event
The 2022 Tomato News Conference
Our supporting partners